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응용화학생명공학과

교수정보의 상세 화면
이재성
이름
이재성
학력
박사
전공
응용화학생명공학전공(과)
정보
연구실 :

연구실번호 :
0312193896

이메일 :
jaeseonglee@ajou.ac.kr

연구관심분야 :
치료용 단백질 생산, 동물세포공학, 동물세포 시스템 및 합성생물학

홈페이지 :
https://www.mcdlab.org/
학력
졸업연도/학교/학위
2012.02 한국과학기술원 박사
졸업연도/학교/학위
2007.02 한국과학기술원 학사
경력 2016. 01. - 2017. 08. Research Scientist, The Novo Nordisk Foundation Center for Biosustainability, DTU, Denmark
2013. 02. - 2015. 12. Post-doctoral Fellow, The Novo Nordisk Foundation Center for Biosustainability, DTU, Denmark
2012. 02. - 2013. 01. Post-doctoral Fellow, Biological Sciences, KAIST, Korea
연구분야 Mammalian cell culture for therapeutic protein production
Mammalian cell line engineering - Genome engineering/Metabolic engineering
Genome editing technologies
Tool development for mammalian synthetic biology 
Omics technologies - Genomics/Transcriptomics/Proteomics
논문 및 연구활동
연구활동(주요논문)
  • [논문] 이재성, 박진형, Helene Faustrup Kildegaard, Mojtaba Samoudi, Nathan E. Lewis, Bernhard O. Palsson, 이균민, 하태광, Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing , ACS SYNTHETIC BIOLOGY (Nov, 2018)
  • [논문] 이재성, Helene Faustrup Kildegaard, 이균민, Lasse Ebdrup Pedersen, Lise Marie Grav, Accelerated homology-directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment , BIOTECHNOLOGY AND BIOENGINEERING , Vol.113 , No.11 , pp.2518 -2523 (Jun, 2016)
  • [논문] 이재성, Helene Faustrup Kildegaard, Lise Marie Grav, Signe Gerling, Lasse Ebdrup Pedersen, Anders Holmgaard Hansen, Stefan Kol, 이균민, Thomas Beuchert Kallehauge, One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment , BIOTECHNOLOGY JOURNAL , Vol.10 , No.9 , pp.1446 -1456 (Sep, 2015)
  • [논문] 이재성, Nathan E. Lewis, Lise Marie Grav, Helene Faustrup Kildegaard, CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives , BIOTECHNOLOGY JOURNAL , Vol.10 , pp.979 -994 (Jul, 2015)
  • [논문] 이재성, Lasse Ebdrup Pedersen, Thomas Beuchert Kallehauge, Helene Faustrup Kildegaard, Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway , SCIENTIFIC REPORTS , Vol.5 , pp.8572 -8572 (Feb, 2015)
국제학술논문지
  • [논문] Nathan E. Lewis, Karen Julie la Cour Karottki, Hooman Hefzi, Kai Xiong, Isaac Shamie, Songyuan Li, Lasse Ebdrup Pedersen, Shangzhong Li, 이균민, Helene Faustrup Kildegaard, 이재성, Anders Holmgaard Hansen, Awakening dormant glycosyltransferases in CHO cells with CRISPRa , BIOTECHNOLOGY AND BIOENGINEERING , pp.1 -6 (Oct, 2019)
  • [논문] 이재성, Nathan E. Lewis, 이균민, Helene Faustrup Kildegaard, Mitigating Clonal Variation in Recombinant Mammalian Cell Lines , TRENDS IN BIOTECHNOLOGY , pp.931 -942 (Sep, 2019)
  • [논문] Helene Faustrup Kildegaard, Jose Manuel Camacho-Zaragoza, Daria Sergeeva, 이재성, CRISPR/Cas9 as a Genome Editing Tool for Targeted Gene Integration in CHO Cells , Methods in molecular biology (Clifton, N.J.) , Vol.1961 , pp.213 -232 (Mar, 2019)
  • [논문] Helene Faustrup Kildegaard, Kai Xiong, Kim Fabiano Marquart, Karen Julie la Cour Karottki, Shangzhong Li, Signe Gerling, Nan Cher Yeo, Alejandro Chavez, 이균민, Nathan E. Lewis, 이재성, Isaac Shamie, Reduced apoptosis in Chinese hamster ovary cells via optimized CRISPR interference. , BIOTECHNOLOGY AND BIOENGINEERING , Vol.116 , No.7 , pp.1813 -1819 (Mar, 2019)
  • [논문] 이재성, 박진형, Helene Faustrup Kildegaard, Mojtaba Samoudi, Nathan E. Lewis, Bernhard O. Palsson, 이균민, 하태광, Revealing Key Determinants of Clonal Variation in Transgene Expression in Recombinant CHO Cells Using Targeted Genome Editing , ACS SYNTHETIC BIOLOGY (Nov, 2018)
  • [논문] Michael K. Jensen, Søren D. Petersen, Jie Zhang, Lise M. Grav, Helene F. Kildegaard, Jay D. Keasling, 이재성, Tadas Jakoˇ ci ?unas1, Modular 5'-UTR hexamers for context-independent tuning of protein expression in eukaryotes. , NUCLEIC ACIDS RESEARCH (Aug, 2018)
  • [논문] Helene Faustrup Kildegaard, Lise Marie Grav, Daria Sergeeva, Igor Marin de Mas, Mikael Rørdam Andersen, Lars Keld Nielsen, 이균민, 이재성, Nathan E. Lewis, Minimizing Clonal Variation during Mammalian Cell Line Engineering for Improved Systems Biology Data Generation. , ACS SYNTHETIC BIOLOGY (Jul, 2018)
  • [논문] 이균민, Eric Baek, 이재성, Untangling the mechanism of 3-methyladenine in enhancing the specific productivity: Transcriptome analysis of recombinant Chinese hamster ovary cells treated with 3-methyladenine. , BIOTECHNOLOGY AND BIOENGINEERING , Vol.115 , No.9 , pp.2243 -2254 (Jun, 2018)
  • [논문] 이재성, Karen Julie la Cour Karottki, Lise Marie Grav, Helene Faustrup Kildegaard, Application of CRISPR/Cas9 Genome Editing to Improve Recombinant Protein Production in CHO Cells , Methods in molecular biology (Clifton, N.J.) , pp.101 -118 (May, 2017)
  • [논문] 이재성, Hooman Hefzi, Dong-Yup Lee, Nicole Borth, Lars K.Nielsen, Mikael R.Andersen, Bernhard O.Palsson, Michael J.Betenbaugh, Ziomara P.Gerdtzen, Bjørn G.Voldborg, Helene F.Kildegaard, Juergen Zanghellini, Alyaa M.Abdel-Haleem, Alex Thomas, Harish Nagarajan, Anne Mathilde Lund, Zachary A.King, Jahir M.Gutierrez, Lasse E.Pedersen, Philipp N.Spahn, Nicolas Loira, Giuseppe Paglia, Shangzhong Li, Johnny Arnsdorf, Tune Wulff, Lake-Ee Quek, Daniel C.Zielinski, Natalia E.Jim?nez, Sarantos Kyriakopoulos, Veronica S.Martinez, Daniel Ley, Yingxiang Huang, Deniz Baycin-Hizal, Camila A.Orellana, Meiyappan Lakshmanan, David Ruckerbauer, Aarash Bordbar, Michael Hanscho, Kok Siong Ang, Nathan E.Lewis, A Consensus Genome-scale Reconstruction of Chinese Hamster Ovary Cell Metabolism , CELL SYSTEMS , Vol.3 , No.5 , pp.434 -443 (Nov, 2016)
  • [논문] 이재성, Helene Faustrup Kildegaard, 이균민, Lasse Ebdrup Pedersen, Lise Marie Grav, Accelerated homology-directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment , BIOTECHNOLOGY AND BIOENGINEERING , Vol.113 , No.11 , pp.2518 -2523 (Jun, 2016)
  • [논문] 이균민, 김미겸, 김채린, 이재성, Eric Baek, Chemical inhibition of autophagy: Examining its potential to increase the specific productivity of recombinant CHO cell lines , BIOTECHNOLOGY AND BIOENGINEERING , pp.1953 -1961 (Mar, 2016)
  • [논문] 이재성, Helene Faustrup Kildegaard, Lise Marie Grav, Signe Gerling, Lasse Ebdrup Pedersen, Anders Holmgaard Hansen, Stefan Kol, 이균민, Thomas Beuchert Kallehauge, One-step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment , BIOTECHNOLOGY JOURNAL , Vol.10 , No.9 , pp.1446 -1456 (Sep, 2015)
  • [논문] 이재성, Nathan E. Lewis, Lise Marie Grav, Helene Faustrup Kildegaard, CRISPR/Cas9-mediated genome engineering of CHO cell factories: Application and perspectives , BIOTECHNOLOGY JOURNAL , Vol.10 , pp.979 -994 (Jul, 2015)
  • [논문] 이재성, Lasse Ebdrup Pedersen, Thomas Beuchert Kallehauge, Helene Faustrup Kildegaard, Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway , SCIENTIFIC REPORTS , Vol.5 , pp.8572 -8572 (Feb, 2015)
국제학술발표
  • [학술회의] 이재성, 하태광, 이균민, Nathan E. Lewis, Bernhard O. Palsson, Helene Faustrup Kildegaard, 박진형, Mojtaba Samoudi, Genomic Understanding of Variation in Transgene Expression in CHO , 26th Meeting of the European Society for Animal Cell Technology (May, 2019)
국내학술발표
  • [학술회의] 이재성, 신성욱, An Optimized Strategy for Efficient Multiple Targeted Integration with CRISPR/Cas9-mediated Homology-Directed Repair Pathway in CHO cells , 2019 KSBB Fall Meeting and International Symposium (Oct, 2019)
  • [학술회의] 이재성, Advancing Cell Line Development in the Era of Genome Editing , 2019 KSBB Fall Meeting and International Symposium (Oct, 2019)
  • [학술회의] 이재성, Next Generation Cell Line Development Platform for Therapeutic Protein Production , KMB 2018 Annual Meeting & International Symposium (Jun, 2018)
  • [학술회의] 이재성, Designing mammalian cells for production of tailor-made biopharmaceuticals , 2017 한국공업화학회 추계 총회 및 학술대회 (Nov, 2017)
  • [학술회의] 이재성, Designing Mammalian Cells toward Controlled and Efficient Production of Therapeutic Proteins , 2017 KSBB Fall Meeting and International Symposium (Oct, 2017)
저서 및 번역
  • [저서] Helene Faustrup Kildegaard, Karen Julie la Cour Karottki, 이재성, Daria Sergeeva, Cell Culture Engineering: Recombinant Protein Production, Chapter 8. CRISPR Toolbox for Mammalian Cell Engineering , pp.185-206 (Sep, 2019)
  • [저서] 이재성, 이균민, 하태광, Cell Culture Engineering: Recombinant Protein Production, Chapter 1. Platform Technology for Therapeutic Protein Production , pp.1-22 (Sep, 2019)
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